Table 3 Acquired neutropenia - main causes and method of the diagnosis
From: Congenital neutropenia: diagnosis, molecular bases and patient management
Main category | How to made the diagnosis | Causes in detail (not exhaustive...) |
|---|---|---|
Drug related neutropenia | questioning Safety data | Cytostatic drugs - almost all except asparaginase Anti-infectives penicillins cephalopsorins sulfamids zidovudine acyclovir lévamisole pyrimethamine tranquilisants chlorpromazine phenothiazines anti seizure phenytoin arbamazepine antithyroid drugs propylthiouracil Cardio vascular drug procainamide quinidine Anti rheumatic drugs Gold salts Non steroid ant inflammatory drug colchicine aminopyrine D penicillamine |
Toxic | Context/questioning | Benzene Ionizing radiation |
Infection | Germ isolation or serology or any other probes | Typhoid Brucellae gram negative septicemia Mycobacterium Tuberculosis HIV EBV CMV Parvovirus varicela/Zoster A B C hepatitis,. almost all virus Leishmaniasis paludism |
Acquired malignant or benign hemopathy | Bone marrow smear Bone marrow trephine Bone marrow cytogenetic | Acute leukemia Bone marrow metastases Aplastic idiopathic anemia Myelodysplasia Macrophage activation syndrome/hemophagocytic lymphohistiocytosis |
auto-immunity | Auto Antibodies/Bone marrow smear - almost normal but sometimes Neutrophil Hemophagocytosis | Primitive or secondary to rhumatoid disease like in Felty syndrome |
Large granular lymphocytosis | Blood cytology (> 0.4 G/l LGL) Immunophenotype Lymphoid clonality | Large Lymphocyte Hyperlymphocytosis |
Endocrinopathy | Hormonal dosage | Hyper/Hypothyroidy Surrénal deficiency Pan hypopitutarism |
Nutrition deficiency | Clinical examination Body mass index Vitamin and oligo element dosage | Anorexia nervosia, Marasmus, Copper insufisiency.. |
Idiopathic | No others cause | Â |