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Table 3 Acquired neutropenia - main causes and method of the diagnosis

From: Congenital neutropenia: diagnosis, molecular bases and patient management

Main category How to made the diagnosis Causes in detail (not exhaustive...)
Drug related neutropenia questioning
Safety data
Cytostatic drugs - almost all except asparaginase
Anti-infectives penicillins cephalopsorins sulfamids zidovudine acyclovir lévamisole pyrimethamine tranquilisants chlorpromazine phenothiazines anti seizure phenytoin arbamazepine antithyroid drugs propylthiouracil Cardio vascular drug procainamide quinidine
Anti rheumatic drugs Gold salts Non steroid ant inflammatory drug colchicine aminopyrine D penicillamine
Toxic Context/questioning Benzene Ionizing radiation
Infection Germ isolation or serology or any other probes Typhoid Brucellae gram negative septicemia
Mycobacterium Tuberculosis
HIV EBV CMV Parvovirus varicela/Zoster A
B C hepatitis,. almost all virus
Leishmaniasis paludism
Acquired malignant or benign hemopathy Bone marrow smear
Bone marrow trephine
Bone marrow cytogenetic
Acute leukemia
Bone marrow metastases
Aplastic idiopathic anemia
Macrophage activation syndrome/hemophagocytic lymphohistiocytosis
auto-immunity Auto Antibodies/Bone marrow smear - almost normal but sometimes Neutrophil Hemophagocytosis Primitive or secondary to rhumatoid disease like in Felty syndrome
Large granular lymphocytosis Blood cytology (> 0.4 G/l LGL) Immunophenotype Lymphoid clonality Large Lymphocyte Hyperlymphocytosis
Endocrinopathy Hormonal dosage Hyper/Hypothyroidy
Surrénal deficiency
Pan hypopitutarism
Nutrition deficiency Clinical examination
Body mass index
Vitamin and oligo element dosage
Anorexia nervosia, Marasmus, Copper insufisiency..
Idiopathic No others cause