Figure 6
From: Lack of a synergistic effect of a non-viral ALS gene therapy based on BDNF and a TTC fusion molecule
Motor neuron survival in SOD1G93A mice. A. Representative micrographs showing cross-sections of lumbar spinal cords stained with cresyl violet from wild-type, a, SOD1G93A control (positive control), b, BDNF-treated, c, and BDNF-TTC-treated, d, mice at 16 weeks of age. Bar = 500 μm. B. Histogram representation of the average number of stained motoneurons per section in L2 and L4 spinal cord segments of wild-type littermates, control SOD1G93A and treated mice (n = 4-5 mice per group). * p < 0.05 vs. wild type; # p < 0.05 vs. SODG93A control mice.