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Table 1 Estimated Birth Prevalence of MPS VI.

From: Mucopolysaccharidosis VI

Reference Country
(sub-population data within citations in parentheses)
Study Years Number of diagnosed patients with MPS VI Prevalence per 105 live births Incidence Rate Per Total Live Births MPS VI as % of total MPS diseases for each country.
Meikle et al 1999[8] Australia 1980-1996 18** 0.43 1 in 248,372 10.36%
Nelson et al 2003[117] Western Australia 1969-1996 2 0.31 1 in 320,589 *
Coelho et al 1997[11] Brazil 1982-1995 39 * * 18.48%
Applegarth et al 2000[118] British Columbia, Canada 1972-1996 1 0.1 1 in 1,035,816 5.0%
Lowry et al 1990[119]*** British Columbia, Canada 1962-1986 1 * 1 in 936,572 5.7%
Baehner et al 2005[6] Germany
(Turks in Germany)
1980-1995 31
(16)
0.23
(2.3)
1 in 432,610
(1 in 43,261)
6.96%
(4.42%)
Michelakakis et al 1995[120] Greece 1982-1994 3 * * *
Poorthuis et al 1999[9] Netherlands 1970-1990 6 0.15 * 3.30%
Nelson et al 1997[121] Northern Ireland 1958-1985 0 0 Zero cases in 840,000 0
Pinto et al 2004[10] Portugal
(Northern Portugal)
1982-1999
1962-1999
16
(10)
*
(0.42)
*
(1 in 238,095)
*
(16.12%)
Lin et al 2008[122] Taiwan 2000-2006 2 * 1 in 833,000 *
Malm et al 2008[7] Sweden 1975-2004 2 0.07 1 in 1,505,160 4%
  Norway 1979-2004 1 0.07 1 in 1,455,813 2%
  Denmark 1975-2004 2 0.05 * 3%
  1. *Data not available.
  2. **Prenatal and postnatal data.
  3. ***Lowry et al, 1990[119] reported one case over a 44-year period from 1952-1986, although this period includes a period prior to the first description of MPS VI in 1963. It is unclear if this is the same case reported by Applegarth et al, 2000[118], for the same population. Also the period given in Table 1 by Lowry et al, 1990[119], is corrected from the previously cited birth prevalence in MPS VI literature to represent here the live births reported in the more accurate period from 1962 to 1986 as this is the closest period in the report to the first description of MPS VI in 1963.