Mucopolysaccharidosis VI

Table 1 Estimated Birth Prevalence of MPS VI.

Reference	Country (sub-population data within citations in parentheses)	Study Years	Number of diagnosed patients with MPS VI	Prevalence per 10⁵ live births	Incidence Rate Per Total Live Births	MPS VI as % of total MPS diseases for each country.
Meikle et al 1999[8]	Australia	1980-1996	18**	0.43	1 in 248,372	10.36%
Nelson et al 2003[117]	Western Australia	1969-1996	2	0.31	1 in 320,589	*
Coelho et al 1997[11]	Brazil	1982-1995	39	*	*	18.48%
Applegarth et al 2000[118]	British Columbia, Canada	1972-1996	1	0.1	1 in 1,035,816	5.0%
Lowry et al 1990[119]***	British Columbia, Canada	1962-1986	1	*	1 in 936,572	5.7%
Baehner et al 2005[6]	Germany (Turks in Germany)	1980-1995	31 (16)	0.23 (2.3)	1 in 432,610 (1 in 43,261)	6.96% (4.42%)
Michelakakis et al 1995[120]	Greece	1982-1994	3	*	*	*
Poorthuis et al 1999[9]	Netherlands	1970-1990	6	0.15	*	3.30%
Nelson et al 1997[121]	Northern Ireland	1958-1985	0	0	Zero cases in 840,000	0
Pinto et al 2004[10]	Portugal (Northern Portugal)	1982-1999 1962-1999	16 (10)	* (0.42)	* (1 in 238,095)	* (16.12%)
Lin et al 2008[122]	Taiwan	2000-2006	2	*	1 in 833,000	*
Malm et al 2008[7]	Sweden	1975-2004	2	0.07	1 in 1,505,160	4%
	Norway	1979-2004	1	0.07	1 in 1,455,813	2%
	Denmark	1975-2004	2	0.05	*	3%

*Data not available.
**Prenatal and postnatal data.
***Lowry et al, 1990[119] reported one case over a 44-year period from 1952-1986, although this period includes a period prior to the first description of MPS VI in 1963. It is unclear if this is the same case reported by Applegarth et al, 2000[118], for the same population. Also the period given in Table 1 by Lowry et al, 1990[119], is corrected from the previously cited birth prevalence in MPS VI literature to represent here the live births reported in the more accurate period from 1962 to 1986 as this is the closest period in the report to the first description of MPS VI in 1963.

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