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Table 1 Stages during the life of a Huntington's disease patient

From: Huntington's disease: a clinical review

A. Preclinical stage
A1. At-risk stage (50%), one affected parent - Anxiousness for the future
  - Uncertainty about carriership
  - Care for affected parent
A2.Gene carrier, premanifest stage - Certainty about carriership
  - New position in the family
  - Renewed uncertainty about onset
  - Care for affected parent and own family
A3. Transition phase - Strong feelings about changes in cognition
  - Changes in behaviour
  - Changes in motor activity
  - Uncertainty remains
B. Clinical stage  
B1. Clinical stage I - Presentation first symptoms: neurological, cognitive or psychiatric
  - Chorea most prominent symptom
  - Independent in ADL
  - Burden for the family mainly psychological
  - Rare death, unless suicide
B2 Clinical stage II - Motor disturbance more generalised
  - Physical dependence starts
  - Burden for family psychological and physical
  - Death by other cause, suicide, euthanasia
B3. Clinical stage III - Severe generalised motor disturbance
  - Almost complete physical dependence
  - Patient completely dependent on care
  - Burden for family mainly physical
  - Death