Table 3 Summary of studies concerning IVIG for TEN
From: Toxic epidermal necrolysis and Stevens-Johnson syndrome
| Â | Trent | Viard | Prins | Campione | Al-Mutairi | Shortt | Tan | Stella | Rajaratnam | Bachot | Brown | Schneck |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Â | 2003 | 1998 | 2003 | 2003 | 2004 | 2004 | 2005 | 2007 | 2010 | 2003 | 2004 | 2008 |
| Â | (80) | (44) | (73) | (76) | (74) | (78) | (79) | (82) | (81) | (72) | (75) | (69) |
Study design | Retro | Prosp | Retro | Prosp | Prosp | Retro | Retro | Retro | Retro | Prosp | Retro | Retro |
| Â | N/ | N/ | N/ | N/ | N/ | N/ | N/ | Cont | N/ | N/ | N/ | Cont |
| Â | Cont | Cont | Cont | Cont | Cont | Cont | Cont | Â | Cont | Cont | Cont | Â |
Patients | 24 | 10 | 48 | 10 | 12 | 16 | 12 | 23 | 14 | 34 | 24 | 75 |
Detachm.(%) | 44 | 39 | 45 | 49 | 58 | "65" | --- | --- | "44" | 19 | 49 | --- |
Total dose IVIG (g/kg) | 4 | 3 | 3 | 2 | 2-5 | 2.8 | 2 | --- | 3.3 | 2 | 1.6 | 1.9 (0.7-2.3) |
Predicted mortality (SCORTEN/APACHE*) in % | 33 | --- | --- | 35 | --- | 38 * | --- | 35.8 | 36 | 24 | 28.6 | 25 |
Actual mortality in % | 4 | 0 | 12 | 10 | 0 | 25 | 8 | 26 | 21 | 32 | 41.7 | 34 |