Clinical and histological view of granulomatous lesions. A. Typical poikiloderma lesions on the cheek and ear. B. Deeply red-violet granulomatous skin lesions on arms. C. Low power microscopy of the skin lesion reveals superficial and deep inflammation without repercussion on the epidermis, and several lightly stained granulomas, surrounded by inflammatory cells. Haematoxylin and eosin stain, original magnification × 10. D. High power of a granuloma reveals a mixture of epithelioid macrophages, scattered lymphocytes and lack of caseous necrosis; the granuloma is surrounded by a narrow rim of mononuclear inflammatory cells. Haematoxylin and eosin stain, original magnification × 25. E. Immunohistochemical staining highlighted the granulomas, composed of CD68(+) macrophages. Immunohistochemical staining for CD68, original magnification × 10.