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Figure 2 | Orphanet Journal of Rare Diseases

Figure 2

From: The diagnosis of inherited metabolic diseases by microarray gene expression profiling

Figure 2

Principal component analysis-the effect of microarray batch. An experimental batch effect is apparent. The figure shows a projection of the array measured gene expression profiles of all patients onto the plane spanned by the first two principal components (PCs) that is the two axes along which the data vary the most. Each expression profile (filled circles) is coloured according to microarray batch membership. PC1 separates profiles in the light blue batch (toward the left) from those in the yellow batch (toward the right), while PC2 separates grey (toward the top) from purple, salmon and pale red (towards the bottom; Additional file 2 'Samples').

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