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Table 1 Sites of injection for the experiments carried out

From: In vivo effects of antibodies from patients with anti-NMDA receptor encephalitis: further evidence of synaptic glutamatergic dysfunction

Experiment

Site of injection

Working hypothesis

Dose-response studya,b,c

CA1 rFr2

NMDA-R Ab impair the glutamate concentrations in the extra-cellular space

NMDA and AMPA regulationa,b,c,d

CA1

NMDA-R Ab impair the NMDA- and AMPA-mediated regulation of glutamate

Inhibition of glial transporta,b

CA1

NMDA-R Ab impair the glial transport of glutamate

Blockade of GABA-A receptorsa,b

CA1

Bicuculline enhances the concentrations of glutamate in case of pre-treatment with NMDA-R Ab

Infusion of GABAc

rFr2

Infusion of GABA decreases the concentrations of glutamate after administration of pregabalin

Effects on concentrations of nitric oxide (NO)a,b

rFr2

NMDA-R Ab increase the concentrations of NO

  1. aUse of controls' CSF; bUse of patients' CSF; cUse of purified IgG from a patient positive for NMDA-R antibodies; dUse of purified IgGs from a patient positive for anti-Yo antibodies.