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Figure 4 | Orphanet Journal of Rare Diseases

Figure 4

From: In vivo effects of antibodies from patients with anti-NMDA receptor encephalitis: further evidence of synaptic glutamatergic dysfunction

Figure 4

Interaction with GABA-A receptors and infusion of GABA. A: Effects of blockade of GABA-A receptors on glutamate levels following infusion of patients' CSF. In rats infused (INF) with CSF with NMDA-R-Ab (9049; n = 3 rats; grey bars), administration of bicuculline (represented by a hatched rectangle) increased markedly the concentrations of glutamate. The bicuculline-induced increase of glutamate was lower in rats injected with the control solution 9093 (n = 3 rats; white bars). B: Effects of successive administration of pregabalin (PG) and GABA after infusion of purified IgGs of a patient with NMDA-R-Ab (n = 4 rats). Concentrations of glutamate raised markedly with purified IgGs. Basal: T0 min; Post-NMDA-R-Ab (Post-CSF): post-injection at T30 min; Post-PGB: T90 min post-infusion; Post-Gaba: Post-infusion of Gaba 50 μM at T120 min. Values are mean ± SD. **: p < 0.01

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