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Figure 3 | Orphanet Journal of Rare Diseases

Figure 3

From: In vivo effects of antibodies from patients with anti-NMDA receptor encephalitis: further evidence of synaptic glutamatergic dysfunction

Figure 3

Effects of patients' CSF on glutamate receptor functions. A: Effects of infusion of patients' CSF on the NMDA-mediated regulation of glutamate. Groups 1 and 2: n = 8 rats injected with 5 control CSF. Groups 3 and 4: n = 8 rats injected with CSF from 5 patients positive for NMDA-R- Ab. Groups 5 and 6: 4 rats injected with a control CSF and 4 rats injected with one CSF positive for NMDA-R-Ab, respectively. Values are mean ± SEM. B: Effects of AMPA, AMPA blockade (DNQX), combination of NMDA + DNQX and combination of NMDA + AMPA following administration of NMDA-R-Ab. Groups 1, 3 and 5: 4 rats injected with 4 control CSF. Groups 2, 4 and 6: 4 rats injected with CSF from 4 patients with NMDA-R-Ab. Group 7: 4 rats injected with 1 control CSF. Group 8: 4 rats injected with 1 CSF with NMDA-R-Ab. Values are mean ± SEM. *: p < 0.05; **: p < 0.01

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