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Table 2 Early signs and symptoms of Fabry disease

From: Fabry disease

Organ system Sign/Symptom
Nervous system Acroparesthesias
  Nerve deafness
  Heat intolerance
  Hearing loss, tinnitus
Gastrointestinal tract Nausea, vomiting, diarrhoa
  Postprandial bloating and pain, early satiety
  Difficulty gaining weight
Skin Angiokeratomas
  Hypohidrosis
Eyes Corneal and lenticular opacities
  Vasculopathy (retina, conjunctiva)
Kidneys Microalbuminuria, proteinuria
  Impaired concentration ability
  Hyperfiltration
  Increased urinary Gb3 excretion
Heart Impaired heart rate variability
  Arrhythmias
  ECG abnormalities (shortened PR interval)
  Mild valvular insufficiency