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Table 3 Interactions in α-thalassaemia

From: α-thalassaemia

  

α+

α0

  

α α

α αT

- α

αTα

- αT

- -

(αα)

α0

- -

T

H

H

H, Hy

H

Hy

 
 

(αα)

T

 

H

    

α+

- αT

T

Unk

H

T

H

  
 

αTα

T

Unk

T

T, H

   
 

- α

T

Unk

T

    
 

α αT

T

Unk

     
 

α α

N

      
  1. Abbreviations: (αα), non-deletion α0 thalassaemia (due to upstream deletion); --, deletion α0 thalassaemia;
  2. N, non-thalassaemic; T, α-thalassaemia trait; H, HbH disease; Hy, Bart's hydrops foetalis syndrome; Unk, unknown, not observed yet. The severity of the condition, thalassaemia trait or HbH disease is determined by the severity of down-regulation by the non-deletion mutant, this remains to be determined through further observation (adapted from Weatherall and Clegg 2001)[5].
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Orphanet Journal of Rare Diseases

ISSN: 1750-1172