Skip to main content

Table 9 Relative RYR 1 allele ratios of LCLs after incubation with actinomycin D

From: Allele-specific differences in ryanodine receptor 1 mRNA expression levels may contribute to phenotypic variability in malignant hyperthermia

Normalized ratios LCL #5 Actinomycin D incubation time (h) mean ± stdev.
  0 2 7 24
Wild type RYR1 (CV%) 1.22 ± 0.25 (20.70%) 1.44 ± 0.24 (16.83%) 1.43 ± 0.22 (15.17%) 1.12 ± 0.07 (6.24%)
Mutant RYR1 1.00 1.00 1.00 1.00
Normalized ratios LCL #6     
Wild type RYR1 (CV%) 1.86 ± 0.28 (15.21%) 1.82 ± 0.15 (8.14%) 1.86 ± 0.43 (23.38%) 1.67 ± 0.17 (10.05%)
Mutant RYR1 1.00 1.00 1.00 1.00
  1. Stdev. = Standard deviation, CV%= coefficient of variance.