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Table 7 Relative RYR1 allele ratios in muscle tissues (n = 3)

From: Allele-specific differences in ryanodine receptor 1 mRNA expression levels may contribute to phenotypic variability in malignant hyperthermia

Normalized ratios

Muscle sample

Mean ± stdev.

#1

#2

#3

#4

Wild type RyR1 (CV%)

1.76 ± 0.08 (4.35%)

1.72 ± 0.27 (15.49%)

1.44 ± 0.14 (9.86%)

2.44 ± 0.40 (16.50%)

Mutant RyR1

1.00

1.00

1.00

1.00

IVCT data

    

Maximum caffeine tension (g)

3.8

2.0

1.9

2.9

Maximum halothane tension (g)

3.2

6.6

2.6

7.0

  1. Stdev. = Standard deviation, CV%= coefficient of variance.
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Orphanet Journal of Rare Diseases

ISSN: 1750-1172