Orodental phenotype and genotype findings in all subtypes of hypophosphatasia

Table 1 Dental phenotypes of 5 cases of HP

Dental features	1 infantile born in 1971	2 infantile born in 1998	3 childhood born in 2003	4 childhood born in 2004	5 childhoodHP born in 2002
Age at diagnosis	2 y	6 m	10 m	2,5 y	2,5 y
Age at examination	36 y	9 y	1 y	1 y	2,5 y
Loss of teeth < 1 year of age	+	+	+	-	-
Loss of posterior teeth	+	+	mobility	-	-
Inflammation of the gingiva Anomalies	-	-	-	-	-
number	-	-	-	-	-
shape: crowns	+	+	-	-	-
shape: roots and pulp chambers	+	+	+	+	+
size	-	-	-	-	-
structure	+	+	-	-	-
Impaction	-	+	+	-	-
Delay in eruption	+	+	+	-	-
Atrophy of alveolar bone	+	+	+	+	+
Type of dental phenotype	severe	severe	severe	moderate	moderate

Dental phenotype: a severe phenotype is associated with premature loss of teeth before 1 year of age and at least 3 types of dental anomalies. Moderate phenotype is associated with premature loss of teeth after 1 year of age and less than 3 types of dental anomalies.
Symbols: +: present, -: absent, m: months, y: year

ISSN: 1750-1172