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Table 2 Familial ALS (fALS) gene mutations and clinical features
| Familial ALS type | Locus (gene address) | Gene | Inheritance | Clinical pattern | Mutations | Causes sporadic disease |
|---|---|---|---|---|---|---|
| ALS1 | 21q | SOD1 | AD | Classical | > 120 | yes |
| ALS2 | 2q33 | ALSIN | AR | Young onset, UMN | 10 | no |
| ALS3 | 18q21 | AD | Classical | not known | not known | |
| ALS4 | 9q34 | SETX | AD | Young onset, slow | 3 | Probably not |
| ALS5 | 15q15 | not known | AR | Young onset | not known | Probably not |
| ALS6 | 16q21 | not known | AD | Classical | not known | not known |
| ALS7 | 20ptel-p13 | not known | AD | Classical | not known | not known |
| ALS8 | 20q13.3 | VAPB | AD | Varied | 1 | no |
| ALS-FTD | 9q21-q22 | not known | AD | With FTD | not known | not known |
| ALS-FTD | 9p21.3 | not known | AD | With FTD | not known | not known |
| ALS | 14q11.2 | Angiogenin | AD | Classical | 6 | Yes |
| FTD (FTD3) | 3 | CHMP2B | AD | FTD (ALS) | 2 | not known |
| ALS | 1 | TDP43 | AD | ALS | 14 | Yes |
| LMND | 2p13 | DCTNI | AD | LMND | 1 (+ 4 in ALS?) | Yes? |
