|
Familial ALS type
|
Locus (gene address)
|
Gene
|
Inheritance
|
Clinical pattern
|
Mutations
|
Causes sporadic disease
|
|---|
|
ALS1
|
21q
|
SOD1
|
AD
|
Classical
|
> 120
|
yes
|
|
ALS2
|
2q33
|
ALSIN
|
AR
|
Young onset, UMN
|
10
|
no
|
|
ALS3
|
18q21
| |
AD
|
Classical
|
not known
|
not known
|
|
ALS4
|
9q34
|
SETX
|
AD
|
Young onset, slow
|
3
|
Probably not
|
|
ALS5
|
15q15
|
not known
|
AR
|
Young onset
|
not known
|
Probably not
|
|
ALS6
|
16q21
|
not known
|
AD
|
Classical
|
not known
|
not known
|
|
ALS7
|
20ptel-p13
|
not known
|
AD
|
Classical
|
not known
|
not known
|
|
ALS8
|
20q13.3
|
VAPB
|
AD
|
Varied
|
1
|
no
|
|
ALS-FTD
|
9q21-q22
|
not known
|
AD
|
With FTD
|
not known
|
not known
|
|
ALS-FTD
|
9p21.3
|
not known
|
AD
|
With FTD
|
not known
|
not known
|
|
ALS
|
14q11.2
|
Angiogenin
|
AD
|
Classical
|
6
|
Yes
|
|
FTD (FTD3)
|
3
|
CHMP2B
|
AD
|
FTD (ALS)
|
2
|
not known
|
|
ALS
|
1
|
TDP43
|
AD
|
ALS
|
14
|
Yes
|
|
LMND
|
2p13
|
DCTNI
|
AD
|
LMND
|
1 (+ 4 in ALS?)
|
Yes?
|
- AD = autosomal dominant; AR = autosomal recessive; CHMP2B = Chromatin modifying protein 2B; DCTNI = dynactin; FTD = frontotemporal lobe dementia; LMND = lower motor neuron disease; SETX = senataxin
- VAPB = Vesicle associated membrane protein.
