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Figure 6 | Orphanet Journal of Rare Diseases

Figure 6

From: Familial adenomatous polyposis

Figure 6

Relationship between Wnt signaling and the APC tumor-suppressor gene in activating the β-catenin to enter the nucleus (no APC activity) for promoting genes expression and polyamine metabolism (ODC) in the colonic epithelium; or (with APC activity) for the proteasomal degradation in the colonic epithelium.

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Orphanet Journal of Rare Diseases

ISSN: 1750-1172