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Table 1 Baseline Characteristics of Patients Entering the Study

From: Early treatment with noninvasive positive pressure ventilation prolongs survival in Amyotrophic Lateral Sclerosis patients with nocturnal respiratory insufficiency

 

FVC > 75%

FVC < 75%

p-value between groups 2–3

 

Group 1

Group 2 (NPPV)

Group3 (not vent)

 

N

44

16

12

 

male/female

27/17

9/7

7/5

 

Age

51.16 (7.39)

55.93 (5.09)

57.54 (6.54)

ns

BMI

22.72 (3.90)

21.98 (4.48)

22.85 (3.16)

ns

Bulbar onset

13/44

5/16

4/12

ns

Spinal onset

23/44

8/16

6/12

ns

FVC%

83.3 (11.84)

65.13 (13.37)

62.35 (12.75)

ns

FEV1%

88.12 (13.98)

64.53 (14.17)

61.6 (13.8)

ns

PaO2 mmHg

90.35 (9.58)

79.91 (12.48)

77.35 (8.54)

ns

PaCO2 mmHg

36.43 (6.72)

41.83 (9.27)

39.48 (8.92)

ns

ALSFRS-R

 

28.7 (6.1)

26.7 (7.1)

ns

  1. Data are presented as mean (± SD); ns = not significant