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Table 1 Primary diagnostic criteria

From: Hereditary sensory neuropathy type I

Main features
Prominent/predominant distal sensory loss
Repeated foot ulcerations/acromutilations
Osteonecrosis
Additional criteria
Variable distal motor involvement
Foot deformity
Autonomic disturbances
Skin changes (hyperkeratosis, blisters, onychomycosis, etc.)
Autosomal dominant inheritance