From: Mixed cryoglobulinemia
Criteria | Serological | Pathological | Clinical |
---|---|---|---|
major | mixed cryoglobulins low C4 | leukocytoclastic vasculitis | purpura |
minor | rheumatoid factor + HCV + HBV + | clonal B-cell infiltrates (liver and/or bone marrow) | chronic hepatitis MPGN peripheral neuropathy skin ulcers |
definite mixed cryoglobulinemia syndrome: | |||
a) serum mixed cryoglobulins (± low C4) + purpura + leukocytoclastic vasculitis | |||
b) serum mixed cryoglobulins (± low C4)+ 2 minor clinical symptoms + 2 minor serological/pathological findings | |||
essential or secondary mixed cryoglobulinemia: | |||
absence or presence of well-known disorders (infectious, immunological or neoplastic) |