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Table 3 Proposed criteria for the classification of mixed cryoglobulinemia (MC) patients.

From: Mixed cryoglobulinemia

Criteria Serological Pathological Clinical
major mixed cryoglobulins
low C4
leukocytoclastic vasculitis purpura
minor rheumatoid factor +
clonal B-cell infiltrates
(liver and/or bone marrow)
chronic hepatitis
peripheral neuropathy
skin ulcers
definite mixed cryoglobulinemia syndrome:
a) serum mixed cryoglobulins (± low C4) + purpura + leukocytoclastic vasculitis
b) serum mixed cryoglobulins (± low C4)+ 2 minor clinical symptoms
+ 2 minor serological/pathological findings
essential or secondary mixed cryoglobulinemia:
absence or presence of well-known disorders (infectious, immunological or neoplastic)
  1. HCV+ or HBV+: markers of hepatitis C virus or hepatitis B virus infection (anti-HCV ± HCV RNA; HBV DNA or HBsAg); MPGN: membranoproliferative glomerulonephritis.