Table 2 Demographic, clinico-serological and virological features of 250 mixed cryoglobulinemia (MC) patients*.
From: Mixed cryoglobulinemia
Clinical features | Â |
|---|---|
Age at disease onset, mean ± SD yrs (range) | 54 ± 13 (29–72) |
Female/Male ratio | 3 |
Disease duration, mean ± SD years (range) | 12 ± 10 (1–40) |
Purpura | 98% |
Weakness | 98% |
Arthralgias | 91% |
Arthritis (non-erosive) | 8% |
Raynaud's phenomenon | 32% |
Sicca syndrome | 51% |
Peripheral neuropathy | 81% |
Renal involvement** | 31% |
Liver involvement | 73% |
B-cell non-Hodgkin's lymphoma | 11% |
Hepatocellular carcinoma | 3% |
Cryocrit, mean ± SD % | 4.4 ± 12 |
Type II/type III mixed cryoglobulins | 2/1 |
C3, mean ± SD mg/dl (normal 60–130) | 93 ± 30 |
C4, mean ± SD mg/dl (normal 20–55) | 10 ± 12 |
Antinuclear antibodies | 30% |
Antimitochondrial antibodies | 9% |
Anti-smooth muscle antibodies | 18% |
Anti-extractable nuclear antigen antibodies | 8% |
anti-HCV Ab ± HCV RNA, % | 92% |
Anti-HBV antibodies | 32% |
HBsAg | 1% |