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Table 2 Demographic, clinico-serological and virological features of 250 mixed cryoglobulinemia (MC) patients*.

From: Mixed cryoglobulinemia

Clinical features  
Age at disease onset, mean ± SD yrs (range) 54 ± 13 (29–72)
Female/Male ratio 3
Disease duration, mean ± SD years (range) 12 ± 10 (1–40)
Purpura 98%
Weakness 98%
Arthralgias 91%
Arthritis (non-erosive) 8%
Raynaud's phenomenon 32%
Sicca syndrome 51%
Peripheral neuropathy 81%
Renal involvement** 31%
Liver involvement 73%
B-cell non-Hodgkin's lymphoma 11%
Hepatocellular carcinoma 3%
Cryocrit, mean ± SD % 4.4 ± 12
Type II/type III mixed cryoglobulins 2/1
C3, mean ± SD mg/dl (normal 60–130) 93 ± 30
C4, mean ± SD mg/dl (normal 20–55) 10 ± 12
Antinuclear antibodies 30%
Antimitochondrial antibodies 9%
Anti-smooth muscle antibodies 18%
Anti-extractable nuclear antigen antibodies 8%
anti-HCV Ab ± HCV RNA, % 92%
Anti-HBV antibodies 32%
HBsAg 1%
  1. * evaluated at the end of the patients' follow-up
  2. **invariably membranoproliferative glomerulonephritis