Figure 3

Different referrals of patients with mixed cryoglobulinemia (MC). Given its clinical polymorphism, the MC syndrome may develop through different, often unpredictable symptoms. Consequently, MC patients may be referred to different specialties according to prevalent or apparently unique clinical manifestation, such as membranoproliferative glomerulonephritis (MPGN) or purpuric skin lesions. Patients with very mild manifestations, often arthralgias and/or serum rheumatoid factor (RF) positivity, are generally referred to rheumatologic clinic.