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Figure 2 | Orphanet Journal of Rare Diseases

Figure 2

From: Mixed cryoglobulinemia

Figure 2

Cutaneous manifestations of mixed cryoglobulinemia (MC). (a) recent onset orthostatic purpura; at this stage the histopathological evaluation shows (b) the classical necrotizing leukocytoclastic vasculitis characterized by diffuse fibrinoid necrosis and disintegrated neutrophil permeation of the vessel walls; (c) symmetrical hyperpigmentation of the skin on the legs after repeated episodes of purpura; both orthostatic purpura and these permanent ochraceous lesions represent the typical skin manifestations of MC; (d) severe vasculitic manifestation; (e) wide skin ulcer, often resistant to treatment.

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