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Table 2 Simulation results of phase IV drop-the-loser design

From: Adaptive design methods in clinical trials – a review

Interim sample size per group Final sample size per group Probability of identifying the optimal arm
25 50 80.3%
50 100 91.3%
  1. Note: response rate for the five arms: 0.4, 0.45, 0.45, 0.5, and 0.6.
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Orphanet Journal of Rare Diseases

ISSN: 1750-1172