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Table 2 Simulation results of phase IV drop-the-loser design

From: Adaptive design methods in clinical trials – a review

Interim sample size per group

Final sample size per group

Probability of identifying the optimal arm

25

50

80.3%

50

100

91.3%

  1. Note: response rate for the five arms: 0.4, 0.45, 0.45, 0.5, and 0.6.