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Table 2 Treatment of the symptoms of PBC

From: Primary biliary cirrhosis

Pruritus

1st line

Cholestyramine 4 g/d (before + after breakfast)

 

2nd line

Rifampin 150 mg bid

 

3rd line

Sertraline (anti-depressant)

 

4th line

Naloxone, by an experienced physician

 

5th line

Liver transplantation

 

Supportive

UV light, Sunlight

 

Emergency

Plasmapheresis

Raynauds

1st line

Ca channel blockers

 

2nd line

Alternative: prostacyclin and its derivatives, endothelin receptor antagonists and phosphodiesterase inhibitors

Sicca syndrome

Dry eyes

Artificial tears

 

Dry mouth

Dental hygiene, dental visit every 3–6 months

 

Dry vagina

Vaginal lubricants