Pruritus | 1st line | Cholestyramine 4 g/d (before + after breakfast) |
 | 2nd line | Rifampin 150 mg bid |
 | 3rd line | Sertraline (anti-depressant) |
 | 4th line | Naloxone, by an experienced physician |
 | 5th line | Liver transplantation |
 | Supportive | UV light, Sunlight |
 | Emergency | Plasmapheresis |
Raynauds | 1st line | Ca channel blockers |
 | 2nd line | Alternative: prostacyclin and its derivatives, endothelin receptor antagonists and phosphodiesterase inhibitors |
Sicca syndrome | Dry eyes | Artificial tears |
 | Dry mouth | Dental hygiene, dental visit every 3–6 months |
 | Dry vagina | Vaginal lubricants |