Table 2 "The face often predicts the brain" [5, 110]. Parallelism of face and brain phenotypes generally observed in HPE.
From: Holoprosencephaly
Group | Morphology | HPE degree |
|---|---|---|
(I) Cyclopia | Single or double eye Proboscis | Alobar |
(II) Ethmocephaly | Distinct sockets Extreme ocular hypotelorism Proboscis | Alobar |
(III) Cebocephaly | Ocular hypotelorism Proboscis, with single nostril | Alobar |
(IVA) | Ocular hypotelorism Midline cleft lip Flat nose | Alobar or Semi-lobar |
(IVB) | Ocular hypotelorism Midline cleft lip (complete or partial) Flat nose | Semi-lobar or lobar |