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Table 1 The four known types of OCA

From: Oculocutaneous albinism

Gene Gene product Chr. localization Size Disease name Prevalence
TYR Tyrosinase (TYR) 11q14.3 65 kb (529aa) OCA1 1:40,000
        OCA1A  
        OCA1B (Yellow alb.)  
OCA2
(p gene)
OCA2 15q11.2-q12 345 kb (838aa) OCA2 (Brown OCA in Africans) 1:36,000 (white Europeans) 1:3,900–10.000 (Africans)
TYRP1 Tyrosinase-related protein 1 (TYRP1) 9p23 17 kb (536aa) OCA3 (Rufous OCA) Rare (white Europeans, Asians) 1:8,500 (Africans)
MATP Membrane-associated transporter protein (MATP) 5p13.3 40 kb (530aa) OCA4 Rare (white Europeans) 1:85,000 (Japanese)