Skip to main content

Table 1 Genetics of Hereditary Sensory and Autonomic Neuropathies (HSAN)

From: Hereditary sensory and autonomic neuropathies: types II, III, and IV

Nomenclature * HSAN type Transmission Chromosomal location Gene
Hereditary sensory radicular neuropathy I AD 9q22.1-22.3 SPTLC1
Congenital sensory neuropathy (CSN) II AR 12p13.33 HSN2 (?)
Familial dysautonomia (FD)/Riley Day III AR 9q31 IKBKAP
Congenital insensitivity to pain with anhidrosis (CIPA) IV AR 1q21-22 NTRK1 (TRKA)
Congenital insensitivity to pain with partial anhidrosis V NK NK NTRK1
Congenital autonomic dysfunction with universal pain loss (CAD)   NK NK  
Progressive panneuropathy   NK NK  
  1. • * HSAN nomenclature from Dyck and Ohta [2]
  2. • NK: not known, AR: autosomal recessive, AD: autosomal dominant