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Table 1 Effect of botulinum toxin on achalasia

From: Idiopathic (primary) achalasia

Study Method Number of patients enrolled % LES pressure decreased post treatment Remission rate at 1 months Remission rate at 6 months Remission rate at 12 months
Pasricha et al, [55] Randomized control trial 21 33% 90% 44% ___
Fishman et al, [56] Prospective study 60 ___ 70% ___ 36%
Gordon et al, [75] Prospective study 16 ___ 75% 48% ___
Vaezi et al, [2] Randomized trial 24 1% 60% 50% 32%
Annese et al, [71] Randomized trial 16 49% 100% ___ 12.5%
Pasricha et al, [58] Prospective study 31 45% 90% 64% ___
Martinek et al, [76] Prospective cohort study 49 65% 93% ___ 41%
Zaninotto et al, [77] Randomized controlled trial 40 ___ ___ 66% 34%