|
Clinical Form
|
---|
Characteristic
|
Classicala
|
Hematologic malignancya
|
Solid tumora
|
Drug-inducedb
|
---|
Epidemiology
| | | | |
Women
|
80
|
50
|
59
|
71
|
Prior upper respiratory tract infection
|
75–90
|
16
|
20
|
21
|
Recurrencec
|
30
|
69
|
41
|
67
|
Clinical symptoms
| | | | |
Feverd
|
80–90
|
88
|
79
|
100
|
Musculoskeletal involvement
|
12–56
|
26
|
34
|
21
|
Ocular involvement
|
17–72
|
7
|
15
|
21
|
Lesion location
| | | | |
Upper extremities
|
80
|
89
|
97
|
71
|
Head and neck
|
50
|
63
|
52
|
43
|
Trunk and back
|
30
|
42
|
33
|
50
|
Lower extremities
|
Infrequent
|
49
|
48
|
36
|
Oral mucous membranes
|
2
|
12
|
3
|
7
|
Laboratory findings
| | | | |
Neutrophiliae
|
80
|
47
|
60
|
38
|
Elevated erythrocyte sedimentation ratef
|
90
|
100
|
95
|
100
|
Anemiag
|
Infrequent
|
82
|
83
|
100
|
Abnormal platelet counth
|
Infrequent
|
68
|
50
|
50
|
Abnormal renal functioni
|
11–50
|
15
|
7
|
0
|
- aPercentages for classical, hematologic malignancy, and solid tumor associated Sweet's syndrome adapted with permission from Cohen PR, Kurzrock R: Sweet's syndrome and cancer. Clin Dermatol 1993;11:149–157 [15]. Copyright 1993, Reprinted with permission from Elsevier Ltd, Oxford, United Kingdom.
- bPercentages for drug-induced Sweet's syndrome adapted with permission from Walker DC, Cohen PR: Trimethoprim-sulfamethoxazole-associated acute febrile neutrophilic dermatosis: case report and review of drug induced Sweet's syndrome. J Am Acad Dermatol 1996;34:918–923 [13]. Copyright 1996, Reprinted with permission from the American Academy of Dermatology, Inc., Elsevier Ltd, Oxford, United Kingdom.
- cRecurrence following oral rechallenge testing in the patients with drug-induced Sweet's syndrome.
- dTemperature greater than 38°C.
- eNeutrophil count greater than 6,000 cells/ul.
- fErythrocyte sedimentation rate greater than 20 mm/hr.
- gHemoglobin less than 13 g/dl in men and less than 12 g/dl in women.
- hPlatelet count less than 150,000/ul or greater than 500,000/ul.
- iThis includes hematuria, proteinuria, and renal insufficiency.