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Table 2 Clinical features in patients with Sweet's syndrome

From: Sweet's syndrome – a comprehensive review of an acute febrile neutrophilic dermatosis

  Clinical Form
Characteristic Classicala Hematologic malignancya Solid tumora Drug-inducedb
Epidemiology     
Women 80 50 59 71
Prior upper respiratory tract infection 75–90 16 20 21
Recurrencec 30 69 41 67
Clinical symptoms     
Feverd 80–90 88 79 100
Musculoskeletal involvement 12–56 26 34 21
Ocular involvement 17–72 7 15 21
Lesion location     
Upper extremities 80 89 97 71
Head and neck 50 63 52 43
Trunk and back 30 42 33 50
Lower extremities Infrequent 49 48 36
Oral mucous membranes 2 12 3 7
Laboratory findings     
Neutrophiliae 80 47 60 38
Elevated erythrocyte sedimentation ratef 90 100 95 100
Anemiag Infrequent 82 83 100
Abnormal platelet counth Infrequent 68 50 50
Abnormal renal functioni 11–50 15 7 0
  1. aPercentages for classical, hematologic malignancy, and solid tumor associated Sweet's syndrome adapted with permission from Cohen PR, Kurzrock R: Sweet's syndrome and cancer. Clin Dermatol 1993;11:149–157 [15]. Copyright 1993, Reprinted with permission from Elsevier Ltd, Oxford, United Kingdom.
  2. bPercentages for drug-induced Sweet's syndrome adapted with permission from Walker DC, Cohen PR: Trimethoprim-sulfamethoxazole-associated acute febrile neutrophilic dermatosis: case report and review of drug induced Sweet's syndrome. J Am Acad Dermatol 1996;34:918–923 [13]. Copyright 1996, Reprinted with permission from the American Academy of Dermatology, Inc., Elsevier Ltd, Oxford, United Kingdom.
  3. cRecurrence following oral rechallenge testing in the patients with drug-induced Sweet's syndrome.
  4. dTemperature greater than 38°C.
  5. eNeutrophil count greater than 6,000 cells/ul.
  6. fErythrocyte sedimentation rate greater than 20 mm/hr.
  7. gHemoglobin less than 13 g/dl in men and less than 12 g/dl in women.
  8. hPlatelet count less than 150,000/ul or greater than 500,000/ul.
  9. iThis includes hematuria, proteinuria, and renal insufficiency.