From: Sweet's syndrome – a comprehensive review of an acute febrile neutrophilic dermatosis
Classicala | Drug-inducedb |
---|---|
(1) Abrupt onset of painful erythematous plaques or nodules | (A) Abrupt onset of painful erythematous plaques or nodules |
(2) Histopathologic evidence of a dense neutrophilic infiltrate without evidence of leukocytoclastic vasculitis | (B) Histopathologic evidence of a dense neutrophilic infiltrate without evidence of leukocytoclastic vasculitis |
(3) Pyrexia >38°C | (C) Pyrexia >38°C |
(4) Association with an underlying hematologic or visceral malignancy, inflammatory disease, or pregnancy, OR preceded by an upper respiratory or gastrointestinal infection or vaccination | (D) Temporal relationship between drug ingestion and clinical presentation, OR temporally-related recurrence after oral challenge |
(5) Excellent response to treatment with systemic corticosteroids or potassium iodide | (E) Temporally-related resolution of lesions after drug withdrawal or treatment with systemic corticosteroids |
(6) Abnormal laboratory values at presentation (three of four): erythrocyte sedimentation rate >20 mm/hr; positive C-reactive protein; >8,000 leukocytes; >70% neutrophils |