Table 2 Main antibodies associated with Paraneoplastic neurological syndromes
Antibodies | Main associated neurological syndromes | Cancer |
|---|---|---|
Hu-Ab (ANNA1-Ab**) | Sensory neuronopathy Encephalomyelitis Chronic gastrointestinal pseudoobstruction Cerebellar ataxia Limbic encephalitis | SCLC |
Yo-Ab (PCA1-Ab**) | Subacute cerebellar ataxia | Ovary, breast, uterus |
CV2-Ab (CRMP5-Ab**) | Cerebellar ataxia Sensory-motor neuropathy Uveitis, retinopathy Encephalomyelitis | SCLC, thymoma |
Ri-Ab (ANNA2-Ab**) | Opsomyoclonus Cerebellar ataxia | Breast, SCLC |
Amphiphysin-Ab | Stiff-person syndrome Sensory neuronopathy Encephalomyelitis | Breast, SCLC |
Tr-Ab | Cerebellar ataxia | Hodgkin's disease |
Ma2-Ab (Ta-Ab**) | Limbic encephalitis | Testicular |
CAR-Ab | Retinopathy | Breast, SCLC |