Table 1 Main paraneoplastic neurological syndromes and associated antibodies
Paraneoplastic neurological syndromes | Frequency of paraneoplastic origin | Main associated tumors | Main frequent associated paraneoplastic antibodies |
|---|---|---|---|
LEMS | 60% | SCLC | VGCC-Ab* |
Subacute cerebellar ataxia | 50% | Ovary, breast SCLC Hodgkin's disease Others | Yo-Ab (PCA1-Ab**) Hu-Ab (ANNA1-Ab**) CV2-Ab (CRMP5-Ab**) Tr-Ab Ma-Ab (Ta-Ab**) |
Opsomyoclonus | 20% | Neuroblastoma Breast, lung | Hu-Ab (ANNA1-Ab**) Ri-Ab (ANNA2-Ab**) |
Sensory neuronopathy | 20% | SCLC | Hu-Ab (ANNA1-Ab**) CV2-Ab (CRMP5-Ab**) |
Limbic encephalitis | 20% | SCLC Testicular SCLC | Hu-Ab (ANNA1-Ab**) CV2-Ab (CRMP5-Ab**) Ma2-Ab (Ta-Ab**) Amphiphysin-Ab |
Encephalomyelitis | 10% | SCLC Others | Hu-Ab (ANNA1-Ab**) CV2-Ab (CRMP5-Ab**) Amphiphysin-Ab Ma2-Ab (Ta-Ab**) |
Retinopathy | NA | SCLC Melanoma | Recoverin-Ab CV2-Ab (CRMP5-Ab**) Rod-bipolar-cell-Ab |
Stiff-person syndrome | 20% | Breast | Amphiphysin-Ab |
Chronic gastrointestinal pseudoobstruction | NA | SCLC | Hu-Ab (ANNA1-Ab**) CV2-Ab (CRMP5-Ab**) |