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Table 1 Main paraneoplastic neurological syndromes and associated antibodies

From: Paraneoplastic neurological syndromes

Paraneoplastic neurological syndromes Frequency of paraneoplastic origin Main associated tumors Main frequent associated paraneoplastic antibodies
LEMS 60% SCLC VGCC-Ab*
Subacute cerebellar ataxia 50% Ovary, breast
SCLC
Hodgkin's disease
Others
Yo-Ab (PCA1-Ab**)
Hu-Ab (ANNA1-Ab**)
CV2-Ab (CRMP5-Ab**)
Tr-Ab
Ma-Ab (Ta-Ab**)
Opsomyoclonus 20% Neuroblastoma
Breast, lung
Hu-Ab (ANNA1-Ab**)
Ri-Ab (ANNA2-Ab**)
Sensory neuronopathy 20% SCLC Hu-Ab (ANNA1-Ab**)
CV2-Ab (CRMP5-Ab**)
Limbic encephalitis 20% SCLC
Testicular
SCLC
Hu-Ab (ANNA1-Ab**)
CV2-Ab (CRMP5-Ab**)
Ma2-Ab (Ta-Ab**)
Amphiphysin-Ab
Encephalomyelitis 10% SCLC Others Hu-Ab (ANNA1-Ab**)
CV2-Ab (CRMP5-Ab**)
Amphiphysin-Ab
Ma2-Ab (Ta-Ab**)
Retinopathy NA SCLC
Melanoma
Recoverin-Ab
CV2-Ab (CRMP5-Ab**)
Rod-bipolar-cell-Ab
Stiff-person syndrome 20% Breast Amphiphysin-Ab
Chronic gastrointestinal pseudoobstruction NA SCLC Hu-Ab (ANNA1-Ab**)
CV2-Ab (CRMP5-Ab**)
  1. *VGCC-Ab are not really paraneoplastic antibodies because they are involved in LEMS but are not independent on the presence of a tumor
  2. **Alternative nomenclature which can be found in the literature