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Table 1 Criteria used in the Clinical Grading Scale for Malignant Hyperthermia

From: Malignant hyperthermia

Clinical Finding Manifestation
Respiratory acidosis End-tidal CO2>55 mmHg; PaCO2>60 mm Hg
Cardiac involvement Unexplained sinus tachycardia, ventricular tachycardia or ventricular fibrillation
Metabolic acidosis Base deficit >8 m/Eql
pH<7.25
Muscle rigidity Generalized rigidity; severe masseter muscle rigidity
Muscle breakdown Serum creatine kinase concentration >20,000/L units; cola colored urine; excess myoglobin in urine or serum; plasma [K+] >6 mEq/L
Temperature increase Rapidly increasing temperature; T >38.8°C
Other Rapid reversal of MH signs with dantrolene. Elevated resting serum creatine kinase concentration.
Family history Consistent with autosomal dominant inheritance