Table 1 Criteria used in the Clinical Grading Scale for Malignant Hyperthermia
From: Malignant hyperthermia
Clinical Finding | Manifestation |
|---|---|
Respiratory acidosis | End-tidal CO2>55 mmHg; PaCO2>60 mm Hg |
Cardiac involvement | Unexplained sinus tachycardia, ventricular tachycardia or ventricular fibrillation |
Metabolic acidosis | Base deficit >8 m/Eql pH<7.25 |
Muscle rigidity | Generalized rigidity; severe masseter muscle rigidity |
Muscle breakdown | Serum creatine kinase concentration >20,000/L units; cola colored urine; excess myoglobin in urine or serum; plasma [K+] >6 mEq/L |
Temperature increase | Rapidly increasing temperature; T >38.8°C |
Other | Rapid reversal of MH signs with dantrolene. Elevated resting serum creatine kinase concentration. |
Family history | Consistent with autosomal dominant inheritance |