Figure 6
From: Neonatal diabetes mellitus: a disease linked to multiple mechanisms
Heterozygous activating mutations in the KCNJ11 and ABCC8 genes encoding the Kir6.2 and SUR1 subunit of the pancreatic beta-cell potassium ATP (KATP) channel cause PNDM. This mutations led to an increase probability of opening of the potassium channel therefore preventing any activation of the voltage dependent calcium channel and any glucose induced insulin secretion.