Linear map of pancreatitis associated mutations within the primary structure of the human cationic trypsinogen. The amino-acid positions affected by the pancreatitis-associated PRSS1 mutations are denoted by asterisks (*). The positions of the most frequent N29I and R122H mutations are indicated. The blue call-out demonstrates the sequence of the trypsinogen activation peptide (TAP) and the mutations found in this region. The highly conserved tetra-aspartate motif in the activation peptide is underlined and bold.