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Table 3 International retinoblastoma classification

From: Retinoblastoma

Stage 0: Patients treated conservatively (subject to presurgical ophthalmologic classifications)
Stage I: Eye enucleated, completely resected histologically
Stage II: Eye enucleated, microscopic residual tumor
Stage III: Regional extensiona
   a) Overt orbital disease
   b) Preauricular or cervical lymph node extension
Stage IV: Metastatic disease
   a) Hematogenous metastasis:
1. single lesion
2. multiple lesions
   b) CNS extension:
1. Prechiasmatic lesion
2. CNS mass
3. Leptomeningeal disease