Figure 6From: Effective NSAID treatment indicates that hyperprostaglandinism is affecting the clinical severity of childhood hypophosphatasiaProstaglandin E2 (PGE2) production by normal and HP fibroblasts exposed to pyridoxal phosphate (PLP) and/or calcium pyrophosphate (CPPD) in vitro. PGE2 concentrations in the culture supernatant of exposed and control fibroblast cultures were assayed using a high sensitivity PGE2 enzyme.Back to article page