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Table 1 The typical AS models

From: Sleep disturbance in Angelman syndrome patients

 

Method

Reference

Ud5m−/p+ mice

Deleting exon 5 (290 nt) from the transcriptional start site in the maternal Ube3a allele

Jiang et al. [29]

Large deletion mice

Deleting ~ 1.6 Mb chromosome including Ube3a gene

Jiang et al. [30]

Ud6m−/p+ mice

A larger deletion of exon 6 (1247 nt) in the Ube3a gene than Ud5m−/p+ mice

Shi et al. [25]

Ube3atm1.1Bdph mice

Ube3amflox/p+ transgenic mice received tamoxifen to induce Cre-mediated deletion of the Ube3a

Monica et al. [31]

Ube3aLacZ mice

Replacing part of exon 15 and full exon 16 of Ube3a gene with the β-galactosidase (LacZ) transcriptional reporter

Miura et al. [32]

Ube3a-YFP reporter mice

Infusing YFP after Ube3a

Dindot et al. [33]

Ube3aIC−KO mice

Deleting the AS imprinting center (IC)

Lewis et al. [34]

  1. Table 1 AS mouse models and the generating methods. These models are developed to explore the underlying mechanism of AS and verify the effectiveness of therapy