Symptom, n (%) | All (N = 280) | Currently treated | Previously treated with ERT (n = 9) | Treatment naïve (n = 28) | Other (n = 9) | ||
---|---|---|---|---|---|---|---|
Agalsidase beta (n = 189) | Agalsidase alfa (n = 19) | Migalastat (n = 26) | |||||
Low energy/fatigue | 201 (72) | 143 (76) | 9 (47) | 18 (69) | 9 (100) | 15 (54) | 7 (78) |
Tingling in hands or feet | 174 (62) | 115 (61) | 11 (58) | 19 (73) | 7 (78) | 15 (54) | 7 (78) |
Pain in hands or feet | 168 (60) | 119 (63) | 4 (21) | 18 (69) | 8 (89) | 12 (43) | 7 (78) |
Ringing in the ears or hearing loss | 151 (54) | 109 (58) | 4 (21) | 17 (65) | 4 (44) | 11 (39) | 6 (67) |
General body pains/pain crises | 143 (51) | 102 (54) | 6 (32) | 11 (42) | 7 (78) | 10 (36) | 7 (78) |
Abdominal/stomach pain | 140 (50) | 97 (51) | 5 (26) | 9 (35) | 7 (78) | 15 (54) | 7 (78) |
Brain fog | 137 (49) | 101 (53) | 6 (32) | 9 (35) | 7 (78) | 10 (36) | 4 (44) |
Skin problems (e.g., angiokeratomas, dry skin) | 132 (47) | 89 (47) | 6 (32) | 15 (58) | 6 (67) | 12 (43) | 4 (44) |
Sleep disturbances | 125 (45) | 89 (47) | 6 (32) | 15 (58) | 4 (44) | 7 (25) | 4 (44) |
Anxiety | 118 (42) | 80 (42) | 7 (37) | 10 (38) | 5 (56) | 11 (39) | 5 (56) |
Other stomach issues (e.g., nausea, vomiting, constipation) | 113 (40) | 74 (39) | 8 (42) | 10 (38) | 4 (44) | 12 (43) | 5 (56) |
Diarrhoea | 112 (40) | 73 (39) | 8 (42) | 10 (38) | 3 (33) | 12 (43) | 6 (67) |
Disturbed sweating (reduced or increased) | 111 (40) | 77 (41) | 7 (37) | 8 (31) | 5 (56) | 8 (29) | 6 (67) |
Depression | 108 (39) | 73 (39) | 8 (42) | 11 (42) | 4 (44) | 6 (21) | 6 (67) |
Headaches/migraines | 106 (38) | 74 (39) | 8 (42) | 11 (42) | 5 (56) | 5 (18) | 3 (33) |
Palpitations or chest pain | 106 (38) | 80 (42) | 4 (21) | 9 (35) | 7 (78) | 5 (18) | 1 (11) |
Shortness of breath | 104 (37) | 77 (41) | 4 (21) | 10 (38) | 6 (67) | 4 (14) | 3 (33) |
Vision problems | 94 (34) | 60 (32) | 5 (26) | 8 (31) | 9 (100) | 8 (29) | 4 (44) |
No desire to engage in social activities | 68 (24) | 50 (26) | 3 (16) | 6 (23) | 3 (33) | 2 (7) | 4 (44) |
Othera | 18 (6) | 12 (6) | 0 (0) | 2 (8) | 1 (11) | 3 (11) | 0 (0) |