Table 1 Infusion time reduction protocol

1st phase (from 1st to 8th infusion)

 500 mL SS with 2 vials (70 mg)

15

280 (4h, 40′)

107

 250 mL SS with 1 vial (35 mg)

15

140 (2h, 20′)

107

2nd phase (from 9th infusion onward)

9th Infusion

 500 mL SS with 2 vials (70 mg)

20

210 (3h, 30′)

143

 250 mL SS with 1 vial (35 mg)

20

105 (1h, 45′)

143

10th Infusion

 500 mL SS with 2 vials (70 mg)

25

168 (2h, 48′)

178

 250 mL SS with 1 vial (35 mg)

25

84 (1h, 24′)

178

11th Infusion

 500 mL SS with 2 vials (70 mg)

30

140 (2h, 20′)

215

 250 mL SS with 1 vial (35 mg)

30

70 (1h, 10′)

215

12th and subsequent Infusions

 500 mL SS with 2 vials (70 mg)

35

120 (2h)

250

 250 mL SS with 1 vial (35 mg)

35

60 (1h)

250