Cronkhite‒Canada syndrome as inflammatory hamartomatous polyposis: new evidence from whole transcriptome sequencing of colonic polyps

Table 1 Baseline characteristics of patients and healthy volunteers in transcriptional analysis group

	Patients in the positive phase of CCS (pCCS)						Healthy Volunteers (HV or Control)				Consistency of Biopsy
	Age	Gender	Tissue	Proximodistal histopathology	Disease status	Glucocorticoid treatment		Age	Gender	Proximodistal histopathology	Time	Location
CCS1	63	Female	Colon	(Ascending colon) mild acute and chronic inflammation	Positive	No	Control1	53	Female	Healthy colon	Yes	Yes
CCS2	56	Female	Colon	(Descending colon) significant acute and chronic inflammation	Positive	No	Control2	60	Male	Healthy colon	Yes	Yes
CCS3	61	Female	Colon	(Descending colon) significant acute and chronic inflammation	Positive	Yes	Control3	83	Female	Healthy colon	Yes	Yes
CCS4	61	Male	Colon	(Terminal ileum, hepatic flexure, transverse colon, splenic flexure) consistent with the intestinal changes seen in CCS	Positive	Yes	Control4	55	Male	Healthy colon	Yes	Yes
CCS5	46	Male	Colon	(Ascending colon) markedly mild acute inflammation and chronic inflammation; (Large polyps in transverse and ascending colon) tubular adenoma of the gland	Positive	No	Control5	48	Male	Healthy colon	Yes	Yes

The positive phase was defined as the occurrence of typical clinical symptoms (including diarrhea and ectodermal changes) and endoscopically visible diffuse or multiple polyps in the gastrointestinal tract. Healthy volunteers were required to have no previous inflammatory disease of the digestive tract diagnosed, normal appearance of colonic mucosa at endoscopy and no multiple polyps of the digestive tract

ISSN: 1750-1172