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Table 2 Primary and secondary outcomes based on ITT analyses with EM: means, standard deviations, effect sizes by group (WEP-CARE, TAU) and assessment time point (baseline, 3MFU, 6MFU) and results of repeated measures ANOVAs within two assessment time points (baseline and 3MFU) and the group variable (WEP-CARE, TAU)

From: A web-based psychological support program for caregivers of children with rare chronic diseases: a randomized controlled trial

Outcome

WEP-CARE

TAU

ANOVA

Controlled effect size d

3MFU: M (SD)

Effect size d between baseline and 3MFU

6MFU: M (SD)

Difference between baseline and 6MFU

Effect size d between baseline and 6MFU

3MFU: M (SD)

Effect size d between baseline and 3MFU

Time (baseline,3MFU)

Interaction (time X group)

GAD-7

7.81 (4.51)

0.83

6.47 (4.42)

3.90; p < .001

1.13

10.67 (4.39)

0.33

F1,206 = 35.68; p < .001

F1,35 = 6.13; p = .016

0.49

FoP-Q-SF

33.90 (9.65)

0.58

30.07 (6.47)

8.24; p < .001

1.22

41.30 (7.97)

− 0.16

F1,119 = 6.54; p = .013

F1,331 =

18.23; p < .001

0.71

PHQ-9

8.27 (4.76)

0.51

6.07 (4.04)

*

1.00

11.19 (4.77)

− 0.08

F1,41

= 5.97; p = .017

F1,74 = 10.79; p = .002

0.60

ULQIE

55.39 (4.85)

0.65

54.41 (3.23)

**

0.57

53.44 (4.94)

0.66

F1,1608 = 13.11; p = .001

F1,2 = 0.016; p = .899

0.29

CHIP-D

27.58 (7.43)

0.45

30.29

(6.27)

− 6,78; p = .001

0.79

23.21 (11.47)

− 0.08

F1,90 = 2.70; p = .105

F1,233 = 7.02;

p = .010

0.47

  1. Note: ITT = intention to treat analysis; EM = the expectation-maximization algorithm; 3MFU = 3-month follow-up; 6MFU = 6-month follow-up
  2. WEP-CARE = a web-based psychological support program for caregivers of children with chronic rare diseases; TAU = Treatment-As-Usual; GAD-7 = Generalized Anxiety Disorder; FoP-Q-SF = the Short Form of the Fear of Progression Questionnaire; PHQ-9 = the Patient Health Questionnaire; *ULQIE = the Ulm Quality of Life Inventory for Parents, raw scores were transformed linearly into a scale ranging from 0 to 100; CHIP-D = the Coping Health Inventory for Parents
  3. * Since the data at 6MFU were not missing completely at random (MCAR), the difference was not tested
  4. ** Sustainability was not tested if time X group interaction was not significant