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Table 2 Comparison between subgroups of patients by type of treatment requested (nusinersen versus risdiplam)

From: Multidisciplinary team meetings in treatment of spinal muscular atrophy adult patients: a real-life observatory for innovative treatments

 

Request for nusinersen (n = 46)

Request for risdiplam (n = 54)

P value

Age at inclusion

39.45

32.63

0.002

Men

25

22

0.272

MFM32 (n)

65.54 (n = 13)

24.80 (n = 10)

0.002

Type 2: n (%)

3 (7.1%)

30 (65.2%)

0.000001

Type 3: n (%)

37 (88.1%)

15 (32.6%)

0.00001

Walking with aid (%)

12 (28.6% = 

3 (6.5%)

0.06

Wheel-chair bound (%)

23 (54.8%)

39 (84.8%)

0.012

Eating alone (%)

29 (85.3%)

15 (38.5%)

0.00001

Eating with help (%)

4 (11.8%)

12 (30.8%)

0.00001

Depending on food (%)

0 (0.0%)

8 (20.5%)

0.0001

Feeding tube (%)

1 (2.9%)

4 (1.3%)

0.00001

Spine fusion surgery (%)

10 (25.0%)

35 (81.4%)

0.0001

No ventilation (%)

35 (85.4%)

16 (36.4%)

0.0001

Non invasive ventilation (%)

6 (14.6%)

18 (40.9%)

0.0001

Invasive ventilation (%)

0 (0.0%)

10 (22.7%)

0.0001

  1. Significant differences between the two groups are indicated in bold (p < 0.005)