Table 3 Impact of setmelanotide in adults (≥ 18 years old; self-reported) with baseline and week-52 IWQOL-Lite data
Baseline | Change from baseline at week 52 | |||
|---|---|---|---|---|
All patients (n = 11) | Patients without cognitive impairment (n = 7) | All patients (n = 11) | Patients without cognitive impairment (n = 7) | |
IWQL-Lite total score, mean (SD) [range] | 74.9 (12.0) [59.0–97.0] | 70.7 (9.8) [59.0–88.0] | + 12.0 (10.3) [1.0–28.0] | + 17.6 (8.9) [1.0–28.0] |
IWQOL-Lite physical function score, mean (SD) [range] | 63.0 (13.3) [48.0–95.0] | 60.0 (7.8) [52.0–73.0] | + 15.3 (11.6) [0.0–34.0] | + 21.7 (9.3) [5.0–34.0] |
IWQOL-Lite sexual life score, mean (SD) [range] | 90.1 (14.2) [63.0–100.0] | 86.7 (15.7) [63.0–100.0] | + 9.3 (13.4) [0.0–37.0] | + 12.4 (14.8) [0.0–37.0] |
IWQOL-Lite work score, mean (SD) [range] | 83.7 (16.2) [50.0–100.0] | 77.9 (17.6) [50.0–100.0] | + 9.5 (14.0) [− 6.0 to 37.0] | + 15.0 (14.8) [0.0–37.0] |
IWQOL-Lite public distress score, mean (SD) [range] | 75.0 (17.7) [50.0–100.0] | 68.6 (13.6) [50.0–95.0] | + 12.7 (15.0) [− 5.0 to 40.0] | + 20.0 (14.1) [− 5.0 to 40.0] |
IWQOL-Lite self-esteem score, mean (SD) [range] | 79.1 (19.1) [32.0–100.0] | 74.3 (21.3) [32.0–100.0] | + 11.1 (15.9) [0.0–50.0] | + 15.4 (18.4) [0.0–50.0] |
BMI, kg/m2, mean (SD) [range] | 47.6 (5.8) [39.4–57.8] | 50.3 (5.3) [43.0–57.8] | − 9.4% (6.7) [− 17.6 to 5.3%] | − 10.1% (7.4) [− 17.6 to 5.3%] |
Maximal hunger, mean (SD) [range] | – | 7.1 (1.2) [5.0–9.0] | – | − 39.6% (21.5) [− 71.4 to 0%] |