Fig. 1

Change in maximal hunger score over time. Weekly mean of the daily maximal hunger score over time across all patients enrolled in the Phase 3 trial with BBS who could self-report hunger (i.e., ≥ 12 years old without cognitive impairment). Patients were randomized to receive 14 weeks of setmelanotide (n = 5 at baseline) or placebo (n = 9 at baseline), followed by 52 weeks of open-label setmelanotide (n = 14 after 52 weeks). Vertical dashed pink line represents the Week-14 time point where all patients transitioned to open-label setmelanotide treatment