Parameters | Double-blinda
| Open-label extensionb
|
---|
A1P mean (SE) | −1.45 (0.23) | −1.45 (0.23) |
Placebo mean (SE) | −2.19 (0.25) | −1.74 (0.25) |
Difference | 0.74 | 0.29 |
Common SD | 2.25 | 2.25 |
Effect size | 0.32 | 0.13 |
N per group |
147
|
946
|
-
SE standard error, SD standard deviation, N number of patients
-
aAnnual rate of lung density change from baseline to 24 months (A1PI versus placebo)
-
bAnnual rate of lung density change from baseline to 24 months (A1PI versus delayed-start A1PI)