The cost of severe haemophilia in Europe: the CHESS study
© The Author(s). 2017
Received: 15 March 2017
Accepted: 22 May 2017
Published: 31 May 2017
Severe haemophilia is associated with major psychological and economic burden for patients, caregivers, and the wider health care system. This burden has been quantified and documented for a number of European countries in recent years. However, few studies have taken a standardised methodology across multiple countries simultaneously, and sought to amalgamate all three levels of burden for severe disease. The overall aim of the ‘Cost of Haemophilia in Europe: a Socioeconomic Survey’ (CHESS) study was to capture the annualised economic and psychosocial burden of severe haemophilia in five European countries.
A cross-section of haemophilia specialists (surveyed between January and April 2015) provided demographic and clinical information and 12-month ambulatory and secondary care activity for patients via an online survey. In turn, patients provided corresponding direct and indirect non-medical cost information, including work loss and out-of-pocket expenses, as well as information on quality of life and adherence. The direct and indirect costs for the patient sample were calculated and extrapolated to population level.
Clinical reports for a total of 1,285 patients were received. Five hundred and fifty-two patients (43% of the sample) provided information on indirect costs and health-related quality of life via the PSC. The total annual cost of severe haemophilia across the five countries for 2014 was estimated at EUR 1.4 billion, or just under EUR 200,000 per patient. The highest per-patient costs were in Germany (mean EUR 319,024) and the lowest were in the United Kingdom (mean EUR 129,365), with a study average of EUR 199,541. As expected, consumption of clotting factor replacement therapy represented the vast majority of costs (up to 99%). Indirect costs are driven by patient and caregiver work loss.
The results of the CHESS study reflect previous research findings suggesting that costs of factor replacement therapy account for the vast majority of the cost burden in severe haemophilia. However, the importance of the indirect impact of haemophilia on the patient and family should not be overlooked. The CHESS study highlights the benefits of observational study methodologies in capturing a ‘snapshot’ of information for patients with rare diseases.
KeywordsCost Burden Haemophilia Health economics Health-related quality of life
Haemophilia is a genetic disorder characterised by a deficiency of a clotting factor in the blood, leading to prolonged bleed events. The disease is carried on the X chromosome and primarily affects males, though female carriers of the gene may exhibit symptoms of mild haemophilia. The two forms of the condition are Haemophilia A (Factor VIII (FVIII) deficiency) and Haemophilia B (Factor IX (FIX) deficiency); Haemophilia A is approximately four times more common than Haemophilia B . The global incidence of haemophilia is approximately 1 per 4,000–5,000 male births; in a given year, approximately 400 boys are born with haemophilia in Europe .
Individuals with severe haemophilia – representing approximately one-third of the haemophilia population in Europe [2, 3] – have factor levels less than 1% of that expected in a healthy person. Such individuals will experience recurrent, spontaneous bleeds, often in the absence of any trauma event ; four-fifths of bleed events occur within the musculoskeletal system . Approximately 90% of people with severe haemophilia experience chronic haemophilic joint disease, characterised by chronic inflammation and progressive joint deformity, in one or more major joints by the age of 30 . As well as joint stiffness and diminished range of motion, individuals with haemophilia experience significant acute pain during bleed events and chronic pain due to arthropathy, leading to disability and impaired quality of life in more than half of cases .
Prior to the 1960s, when clotting factor replacement therapy (CFRT) became widely available, life expectancy of persons with haemophilia (PWH) was very low (<30 years) in comparison to that of the general male population, with haemorrhage as the most prevalent cause of death . Innovations in factor production mean that PWH in nations with developed healthcare systems can now expect a near-normal quality of life and an average lifespan no more than 10 years shorter than that of an unaffected individual [3, 4]. In this current “golden era” of haemophilia care , management of age-related conditions has become a novel necessity for clinicians and PWH [6, 7]. Nevertheless, a continuing major risk associated with the use of CFRT is the development of inhibitors, so-called due to the development of antibodies that inhibit factor uptake. Affected individuals experience poor bleed control and subsequently higher levels of morbidity and mortality  and reduced HRQoL [9, 10]. The cost of treating an individual with an inhibitor can exceed EUR 1 million per year, with regimens of immune tolerance induction (ITI) therapy lasting more than 3 years in rare cases [11, 12].
The objective of the CHESS study was to estimate and extrapolate resource use, costs, and health-related quality of life (HRQOL) for adults with severe haemophilia in the five largest European economies (EU5: France, Germany, Italy, Spain and the United Kingdom (UK)). The psychological, societal, and economic burden of haemophilia has been documented for a number of European countries [13–17]; few studies have taken a standardised methodology across multiple countries simultaneously , and sought to amalgamate all three levels of burden for severe disease. The overall aim of the CHESS study was to capture the annualised economic and psychosocial burden of severe haemophilia in the EU5.
The study population is a sample of adult patients (18 years and over) with severe inherited haemophilia A or B (FVIII/FIX level <1 IU dL−1), drawn approximately in proportion to the population of individuals with haemophilia in each of the five countries participating. Individuals with acquired haemophilia or other clotting factor deficiencies (e.g. von Willebrand disease (VWD), haemophilia C) were excluded, as symptoms of vWD are generally comparable to that of mild or moderate haemophilia , and our sample size would preclude meaningful conclusions for other rare coagulation disorders.
A retrospective, cross-sectional methodology was employed. Data was collected by means of two questionnaires, designed specifically for specialists and patients: the web-based case record forms (CRFs) were used to collect information on direct medical resource utilisation and clinical data based on recorded notes; and the paper patient self-completion form (PSC), given to patients following the consultation, provided complimentary socio-economic information. One hundred and thirty-nine haematologists (and haemophilia care providers (HCPs) in France) based in hospitals and clinics completed up to eight patient CRFs, with a small number providing information for up to 16 patients. In order to minimise the risk of selection bias, physicians were encouraged to recruit the next eligible patients with whom they consulted, irrespective of their reason for consultation.
All patient participants provided informed consent. The study protocol was approved by the Research Ethics Sub Committee of the Faculty of Health and Social care within the University of Chester. The approval stipulated that the study was to be carried out in correspondence with regional and relevant guidelines.
Data collected from clinicians included clinical economic and demographic information, while data collected from patients included indirect and direct non-medical resource use, HRQOL (via the EuroQol EQ-5D-3 L), work productivity impact (via the Work Productivity and Activity Impairment (WPAI) Questionnaire), and therapy adherence (via the Morisky Medication Adherence Scale 8-item (MMAS-8)).
Data was collected between December 2014 and April 2015 and captured a period of 12 months retrospectively. Estimates of healthcare utilisation and costs were then calculated for the 12-month period. The online format of the CRFs ensured that numeric responses were kept within reasonable boundaries, and that infeasible responses (such as the ability to provide two mutually exclusive responses, for instance) were kept to a minimum. Nevertheless, a small amount of post-hoc data processing was conducted based on expert clinical guidance.
National costs for CHESS resource units
Baseline unit price (EUR)
Haematologist visit (per visit)
Nurse visit (per visit)
Other specialist visit (per visit)
Blood test (per test)
Other test/examination (per test)
Drug (per IU)a
Target joint (per procedure)
Bleed event: ward stay (per day)
Bleed event: ICU stay (per day)
Professional caregiver (per hour)
Wage (patient/caregiver) (per hour)
Petrol (per mile)
Scheduled ambulance (per mile)
Ambulatory activity, including: haemophilia-related visits to haematologists and other specialists, paramedical practitioners (nurse specialists, physiotherapists, diet and nutritional support, etc.), and all tests and procedures (e.g. blood tests, diagnostic imaging);
- (2)Haemophilia-related admissions to hospital, based on length of stay, including admission to ICU, and surgical procedure/diagnosis (where applicable):
bleed-related hospital admissions; and
procedures on ‘target’ joints – defined here as areas of chronic synovitis  – including arthroscopy, arthrodesis, arthroplasty, arthrocentesis, and synovectomy;
Use of a professional (paid) care provider.
All factor consumption was reported by the physician. For on-demand regimens, factor consumption for the most recent 3-month period was annualised. For prophylaxis regimens, mean IU per infusion was multiplied by the weekly infusion rate, and annualised.
Loss of earnings by the patient (due to absenteeism and/or early retirement);
Loss of earnings by an informal caregiver (family or friend) (as above);
Transfer payments (e.g. financial aid, state allowances);
Over-the-counter (OTC) medications;
Other medical device, personal aid, or home alteration costs (e.g. walking aids, orthotics);
Alternative therapies (e.g. yoga/Pilates, massage, nutritionist); and
Transport to/from hospital attendances.
Costs associated with temporary and long-term work absence (including early retirement) were valued using the traditional human capital approach (HCA), due to its benefits in terms of transparency and comparability versus that of the newer friction cost approach (FCA) . Patients who reported early retirement due to haemophilia, or who reported that they were unable to work due to haemophilia in the 3 months prior to responding, were costed at the average annual salary (stratified by country). For patients in employment, days of work lost due to bleeds across the preceding 3 months was reported and extrapolated. Whilst information regarding comorbidities was captured in the questionnaire, all direct and indirect costs were limited to those resulting directly from haemophilia-related activity.
Health-related quality of life
Patient outcomes were obtained by means of the self-administered EQ-5D-3 L, a non-disease specific instrument covering the areas of mobility, self-care, everyday activities, pain/discomfort and anxiety/depression . A three-level rating scale is applied to each dimension, with a total of 245 possible health states defined. The questionnaire has been validated in many countries in Europe and is commonly used in economic evaluation and health technology assessment . The values or utilities are indicated on a scale on which death has a value of 0 and perfect health a value of 1, with negative values being possible. Validated country-specific adult value sets obtained via the EuroQol website were used, with the exception of Italy, for which values were taken from literature .
CHESS demographic data
France (N = 272)
Germany (N = 194)
Italy (N = 280)
Spain (N = 218)
UK (N = 321)
CHESS (N = 1,285)
PSCs received (%)
Haemophilia subtype (%)
Age (mean (SD))
Age categories (%)
Treatment strategy: Prophylaxis (%)
Inhibitor history (%)
Patients with coinfection (%)
EQ-5D-3 L index score (mean (SD))
Prevalence of severe haemophilia A and B in CHESS countries (all ages)
Population (X) 
Est. severe pop. (X \( \times \) Y)
Population (X) 
Est. severe pop. (X \( \times \) Y)
All CHESS countries
Total economic burden of illness
Total economic burden of severe haemophilia in the EU5 (EUR)
Total cost per country (EUR)
Total per-patient cost (EUR) (mean (SD))
Percent of total healthcare expenditures in each country
With an overall population of more than 300 million, the EU5 is home to approximately 8,123 people with severe haemophilia A and 1,370 people with severe haemophilia B. The CHESS study aimed to provide a snapshot view of the economic, societal, and psychological burden of severe haemophilia in adults within the EU5. We estimated the mean per-patient annual direct cost of severe haemophilia at EUR 173,102, EUR 313,068, EUR 210,025, EUR 132,329, and EUR 116,963 for France, Germany, Italy, Spain, and the UK, approximately 48, 79, 87, 65, and 34 times higher than the mean per-capita health expenditure in these countries, respectively . Direct medical resource use was the predominant cost driver, with more than 97% of direct costs taken by CFRT, reflecting previous research suggesting that costs of CFRT account for the vast majority of the cost burden [15, 16, 28]. Annual indirect costs averaged just over EUR 6,000 per patient, with marginal variation between countries (range EUR 4,850–8,651). The total economic and societal cost of severe haemophilia in the EU5 in 2014 was estimated at EUR 1.4 billion.
Patients were recruited to the CHESS study via their haematologist or HCP, with a response rate of 43% across the pooled sample. Participation in the study by clinicians and patients was voluntary, and we therefore cannot rule out a degree of selection bias. Because the cost of illness for non-responding patients remains unknown, it is also not possible to assess the extent of the potential bias. The ratio of haemophilia A patients relative to that of haemophilia B in the CHESS cohort (approximately 1:3.5) is more narrow than current epidemiological studies, which place the ratio closer to 1:5 in severe disease . The differential burden between haemophilia A and B is a topic of ongoing research; current evidence suggests that any overrepresentation by haemophilia B may generate more conservative estimates of disease burden, due to milder disease symptoms .
The proportion of patients receiving prophylaxis in the study cohort (57%) broadly matches that of a recent retrospective audit of haemophilia care in the EU5 ; prevalence of diagnosed inhibitors (4.5%) is almost identical to that of a recent study in Portugal (4.7%) , though the study included children (more than half of inhibitors present before the age of 9 years ), as well as mild and moderate haemophilia patients, who are at lower risk of inhibitor development .
Five percent of the CHESS cohort have recorded HCV comorbidity, with the highest rate in Italy (8%); results from the World Federation of Hemophilia Annual Global Survey  suggests that prevalence of HCV among haemophilia patients is upwards of one in ten, with almost half of patients in Germany co-diagnosed. Furthermore, approximately 7% of PWH in the EU5 are HIV-positive [34–36]; we find prevalence in CHESS to be less than half this amount. We suggest that a sampling bias towards non-infected patients may be present to some extent in this study. The implications of any underrepresentation for our burden estimates are uncertain: the extent to which HIV/HCV coinfection impact upon costs of haemophilia is of some dispute in current literature [37, 38], but may be more than 50% higher compared to those with haemophilia alone.
By profiling consulting patients, we draw from a cohort of patients who consult more frequently – maybe because they have difficulty with bleed control, due to joint degeneration, suboptimal therapy, or adherence. It is possible, therefore, that our sample is biased towards those older, more costly, and less adherent patients, and that our extrapolated costs may be an overestimate of the actual disease burden. However, the age distribution of the CHESS cohort is similar to that of another recent study that sourced data directly from haemophilia treatment centres and data registers across the EU5, Belgium and Sweden .
Our study is limited in its cost estimates by the need to use publically available reimbursement data, particularly for hospital admissions, rather than actual costs to hospital providers and patients. Any divergence between these costs may lead to an under- or over-estimate of the actual realised costs. Recall bias regarding consultations and outpatient visits may be present for clinicians, particularly for consultations with other specialists. Smaller payments by patients may also be overlooked when reporting use of devices, aids, and OTC medications. Costs of informal care provision are limited to that of the primary caregiver; informal care and household burden cost estimates were consequently underestimated for households in which additional individuals contributed to informal care.
Randomized controlled trials (RCTs) are the gold standard of evidence generation for health interventions. However, design of RCTs in rare diseases such as haemophilia is difficult due to the limited size of the patient population . Further, there is often disparities between the highly structured environment of an RCT and ‘real world’ practice, particularly in the absence of formal clinical guidelines. Instead, much of the available evidence for rare diseases is based on larger-scale registries, post-authorisation surveillance studies, and observational studies such as CHESS, which have in recent years produced major insights into the treatment and management of individuals with haemophilia .
PWH in the five CHESS countries benefit from major investment of resources for their care and treatment. These patients are likely to obtain first access to novel long-acting and gene-based therapies in haemophilia, and it is therefore important to understand the continuing unmet need within these populations and where these new therapies will fit with current treatment approaches. The estimates of resource use and cost burden within this study are less translatable outside of Western Europe, where haemophilia often remains underdiagnosed and undertreated . In countries where access to CFRT is restricted and many PWH experience major joint damage and deformity by adolescence, the burden of disease will be weighted more towards the psychosocial and employment impact resulting from severe disability and premature mortality .
The results of the CHESS study underscore the wide variety of costs that accompany a rare disease such as haemophilia and the substantial economic burden carried by patients, caregivers, and the health care systems in these countries. Based on other existing studies of this patient group, we believe that the cost estimates from the CHESS cohort extrapolate well to the population of severe haemophilia patients in the EU5. Though the costs of CFRT account for the vast majority of the burden in this patient group, the importance of the indirect impact of haemophilia on the patient and family should not be overlooked. The CHESS study highlights the benefits of observational study methodologies in capturing a ‘snapshot’ of information for patients with rare diseases.
Kind thanks to Ian Jacob (HCD Economics), Andi Mabhala (University of Chester), Declan Noone (European Haemophilia Consortium), and Janice Gidman (University of Chester) for reviewing the manuscript drafts.
This study was supported by unrestricted research grants from Swedish Orphan Biovitrum AB (Sobi) and Novo Nordisk.
Availability of data and materials
The datasets generated and/or analysed during the current study are held under license by the University of Chester and are not publicly available, but are available from the corresponding author on reasonable request.
JOH and DH designed the study protocol. JOH, DH, and CC designed the CRF and PSC. TB and CC analysed the data. JOH and CC wrote the manuscript. LC and DAG provided non-clinical perspective for the study materials and manuscript. All authors read and approved the final manuscript.
The authors declare that they have no competing interests.
Consent for publication
Ethics approval and consent to participate
The study was reviewed by the Research Ethics Sub Committee of the Faculty of Health and Social Care within the University of Chester. Patient consent for use of clinical data was not required (as per European Pharmaceutical Market Research Association (EPhMRA) guidelines). Patient consent was obtained via tick box selection for the PSC element of the study.
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- Berntorp E. Future of haemophilia outcome assessment: registries are key to optimized treatment. J. Intern. Med. 2016:279(6):498-501.Google Scholar
- Mejia-Carvajal C, Czapek EE, Valentino LA. Life expectancy in hemophilia outcome. J Thromb Haemost. 2006;4:507–9.View ArticlePubMedGoogle Scholar
- Darby SC, Kan SW, Spooner RJ, Giangrande PLF, Hill FGH, Hay CRM, et al. Mortality rates, life expectancy, and causes of death in people with hemophilia A or B in the United Kingdom who were not infected with HIV. Blood. 2007;110:815–25.View ArticlePubMedGoogle Scholar
- World Federation of Hemophilia. Frequently asked questions about hemophilia [Internet]. 2012 [cited 2015 Jul 31]. Available from: http://www.wfh.org/en/page.aspx?pid=637#Life_expectancy
- Franchini M, Mannucci PM. Past, present and future of hemophilia: a narrative review. Orphanet J Rare Dis. 2012;7:24.View ArticlePubMedPubMed CentralGoogle Scholar
- Franchini M, Tagliaferri A, Mannucci PM. The management of hemophilia in elderly patients. Clin Interv Aging. 2007;2:361–8.PubMedPubMed CentralGoogle Scholar
- Mauser-Bunschoten EP, van de Putte DE F, Schutgens REG. Co-morbidity in the ageing haemophilia patient: The down side of increased life expectancy. Haemophilia. 2009;15:853–63.View ArticlePubMedGoogle Scholar
- Darby SC, Keeling DM, Spooner RJD, Wan Kan S, Giangrande PLF, Collins PW, et al. The incidence of factor VIII and factor IX inhibitors in the hemophilia population of the UK and their effect on subsequent mortality, 1977–99. J Thromb Haemost. 2004;2:1047–54.View ArticlePubMedGoogle Scholar
- Gringeri A, Mantovani LG, Scalone L, Mannucci PM. Cost of care and quality of life for patients with hemophilia complicated by inhibitors: the COCIS Study Group. Blood. 2003;102:2358–63.View ArticlePubMedGoogle Scholar
- Scalone L, Mantovani LG, Mannucci PM, Gringeri A. Quality of life is associated to the orthopaedic status in haemophilic patients with inhibitors. Haemophilia. 2006;12:154–62.View ArticlePubMedGoogle Scholar
- Rocino A, Cortesi P, Scalone L, Mantovani L, Crea R, Gringeri A. Immune tolerance induction in patients with haemophilia A and inhibitors: effectiveness and cost analysis in an European Cohort (The ITER Study). Haemophilia. 2016;22:96–102.View ArticlePubMedGoogle Scholar
- Knight C. Health economics of treating haemophilia A with inhibitors. Haemophilia. 2005;11 Suppl 1:11–7.View ArticlePubMedGoogle Scholar
- Coppola A, Cerbone AM, Mancuso G, Mansueto MF, Mazzini C, Zanon E. Confronting the psychological burden of haemophilia. Haemophilia. 2011;17:21–7.View ArticlePubMedGoogle Scholar
- Iannone M, Pennick L, Tom A, Cui H, Gilbert M, Weihs K, et al. Prevalence of depression in adults with haemophilia. Haemophilia. 2012;18:868–74.View ArticlePubMedGoogle Scholar
- Henrard S, Devleesschauwer B, Beutels P, Callens M, De Smet F, Hermans C, et al. The health and economic burden of haemophilia in Belgium: a rare, expensive and challenging disease. Orphanet J Rare Dis. 2014;9:39.View ArticlePubMedPubMed CentralGoogle Scholar
- Rocha P, Carvalho M, Lopes M, Araujo F. Costs and utilization of treatment in patients with hemophilia. BMC Health Serv Res. 2015;15:484. BMC Health Services Research.View ArticlePubMedPubMed CentralGoogle Scholar
- Kodra Y, Cavazza M, Schieppati A, De Santis M, Armeni P, Arcieri R, et al. The social burden and quality of life of patients with haemophilia in Italy. Blood Transfus (Trasfusione del sangue). 2014;12 Suppl 3:s567–75.Google Scholar
- Cavazza M, Kodra Y, Armeni P, De Santis M, López-Bastida J, Linertová R, et al. Social/economic costs and quality of life in patients with haemophilia in Europe. Eur J Heal Econ. 2016;17:53–65.View ArticleGoogle Scholar
- Laffan M, Brown SA, Collins PW, Cumming AM, Hill FGH, Keeling D, et al. The diagnosis of von Willebrand disease: a guideline from the UK Haemophilia Centre Doctors’ Organization. Haemophilia. 2004;10:199–217.View ArticlePubMedGoogle Scholar
- Segel J. Cost of illness studies - a primer. North Carolina: RTI International; 2006.Google Scholar
- Mulder K, Llinás A. The target joint. Haemophilia. 2004;10 Suppl 4:152–6.View ArticlePubMedGoogle Scholar
- Hanly P, Timmons A, Walsh PM, Sharp L. Breast and prostate cancer productivity costs: a comparison of the human capital approach and the friction cost approach. Value Health. 2012;15:429–36.View ArticlePubMedGoogle Scholar
- Jönsson B. Revealing the cost of Type II diabetes in Europe. Diabetologia. 2002;45:S5–S12.View ArticleGoogle Scholar
- Dolan P. Modeling valuations for EuroQol health states. Med Care. 1997;35:1095–108.View ArticlePubMedGoogle Scholar
- Drummond MF, Sculpher MJ, Torrance GW, O'Brien BJ, Stoddart GL. Methods for the economic evaluation of health care programmes. Oxford: Oxford University Press; 2005.Google Scholar
- Scalone L, Cortesi PA, Ciampichini R, Belisari A, D’Angiolella LS, Cesana G, et al. Italian Population-Based Values of EQ-5D Health States. Value Heal. 2013;16:814–22. Elsevier.View ArticleGoogle Scholar
- Organization for Economic Co-operation and Development. OECD.stat (database). Health expenditure and financing. [Internet]. [cited 2016 Mar 12]. Available from: http://stats.oecd.org/index.aspx?DataSetCode=SHA
- Zhou Z-Y, Koerper MA, Johnson KA, Riske B, Baker JR, Ullman M, et al. Burden of illness: direct and indirect costs among persons with hemophilia A in the United States. J Med Econ. 2015;18(6)1–9.Google Scholar
- World Federation of Hemophilia. Report on the Annual Global Survey 2015. 2015.Google Scholar
- Mannucci PM, Franchini M. Is haemophilia B less severe than haemophilia A? Haemophilia. 2013;19:499–502.View ArticlePubMedGoogle Scholar
- Berntorp E, Dolan G, Hay C, Linari S, Santagostino E, Tosetto A, et al. European retrospective study of real-life haemophilia treatment. Haemophilia. 2016;23(1):105-14.Google Scholar
- Hay CRM, Palmer B, Chalmers E, Liesner R, Maclean R, Rangarajan S, et al. Incidence of factor VIII inhibitors throughout life in severe hemophilia A in the United Kingdom. Blood. 2011;117:6367–70. American Society of Hematology.View ArticlePubMedGoogle Scholar
- Lee CA, Kessler CM, Varon D, Martinowitz U, Heim M, Hay CRM. Factor VIII inhibitors in mild and moderate-severity haemophilia A. Haemophilia. 1998;4:558–63. Blackwell Science Ltd.View ArticleGoogle Scholar
- World Federation of Hemophilia. World Federation of Hemophilia Report on the Annual Global Survey 2014. 2014.Google Scholar
- World Federation of Hemophilia. World Federation of Hemophilia Report on the Annual Global Survey 2012. 2013.Google Scholar
- World Federation of Hemophilia. World Federation of Hemophilia Report on the Annual Global Survey 2011. 2013.Google Scholar
- Guh S, Grosse SD, McAlister S, Kessler CM, Soucie JM. Health care expenditures for Medicaid-covered males with haemophilia in the United States, 2008. Haemophilia. 2012;18:276–83.View ArticlePubMedGoogle Scholar
- Tencer T, Friedman HS, Li-McLeod J, Johnson K. Medical Costs and Resource Utilization for Hemophilia Patients With and Without HIV or HCV Infection. J Manag Care Pharm. 2007;13:790–8.PubMedGoogle Scholar
- Halpern SD, Karlawish JHT, Berlin JA. The Continuing Unethical Conduct of Underpowered Clinical Trials. JAMA. 2002;288:358.Google Scholar
- Johnson KA, Zhou Z-Y. Costs of care in hemophilia and possible implications of health care reform. Hematology Am Soc Hematol Educ Program. 2011;2011:413–8.PubMedGoogle Scholar
- O’Mahony B, Black C. Expanding hemophilia care in developing countries. Semin Thromb Hemost. 2005;31:561–8.View ArticlePubMedGoogle Scholar
- Kar A, Phadnis S, Dharmarajan S, Nakade J. Epidemiology & social costs of haemophilia in India. Indian J Med Res. 2014;140:19–31.PubMedPubMed CentralGoogle Scholar
- Causemann C. Querschnittsuntersuchung zum altersabhängigen Gelenkstatus und Konzentratverbrauch von Patienten mit einer schweren Hämophilie A oder B im Jahr 2010. Bonn: Rheinische Friedrich-Wilhelms-Universität; 2014.Google Scholar
- Aznar JA, Lucía F, Abad-Franch L, Jiménez-Yuste V, Pérez R, Batlle J, et al. Haemophilia in Spain. Haemophilia. 2009;15:665–75.View ArticlePubMedGoogle Scholar
- United Kingdom Haemophilia Centres Doctors’ Organisation. Bleeding disorder statistics for April 2013 to March 2014. 2014.Google Scholar
- Institut de Veille Sanitaire. Réseau Francecoag - Statistiques nationales: Hémophilie A [Internet]. 2015 [cited 2015 Jul 31]. Available from: http://www.francecoag.org/SiteWebPublic/public/stats/stats_page.jsp?stat2=on
- Abbonizio F, Giampaolo A, Arcieri R, Hassan HJ, AICE (AICE). Registro Nazionale delle Coagulopatie Congenite. Rapporto 2013. Rapp. ISTISAN 15/14. 2015.Google Scholar
- Institut de Veille Sanitaire. Réseau Francecoag - Statistiques nationales: Hémophilie B [Internet]. 2015 [cited 2015 Jul 31]. Available from: http://www.francecoag.org/SiteWebPublic/public/stats/stats_page.jsp?stat3=on