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Fig. 2 | Orphanet Journal of Rare Diseases

Fig. 2

From: Transcranial pulsed ultrasound facilitates brain uptake of laronidase in enzyme replacement therapy for Mucopolysaccharidosis type I disease

Fig. 2

Procedures of ultrasound treatment in MPS I mice and B6 mice. Ultrasound was applied in the left side brain. Acoustic pressure 0.56 MPa, PRF 1 Hz, burst length 10 ms, and ultrasound exposure time 60s were used in all ultrasound treatments. a MPS I mice treated with one-spot ultrasound. b MPS I mice treated with two-spot ultrasound. The total dose of MBs and laronidase used were the same as panel a. c B6 mice treated with one-spot ultrasound. d B6 mice treated with two-spot ultrasound. The total dose of MBs and EB used were the same as panel c

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Orphanet Journal of Rare Diseases

ISSN: 1750-1172