The efficacy of the modified Atkins diet in North Sea Progressive Myoclonus Epilepsy: an observational prospective open-label study

Table 2 Results of the assessments at baseline and at 3 months on the Modified Atkins Diet in four patients with North Sea Progressive Myoclonus Epilepsy

Patient	HRQL^a				UMRS^b				Effect on seizure frequency^c	EEG change^c	Changes in mood and behaviour^c
Patient	Baseline	MAD at 3 months	Change	MAD at 3 years	Baseline	MAD at 3 months	Change	MAD at 3 years	Effect on seizure frequency^c	EEG change^c	Changes in mood and behaviour^c
1	pt. 46	pt. 27	impr. 19 pts	pt 47	71	64	impr. 7 pts	75	No change	No changes	n.d.
1	par. 50	par. 43	impr. 7 pts	par. 37	71	64	impr. 7 pts	75	No change	No changes	n.d.
2	25	31	det. 6 pts	n.a.	72	58	impr. 14 pts	n.a.	No change	No changes	det. IDS 7 pts
3	58	55	impr. 3 pts	n.a.	87	85	impr. 2 pts	n.a.	No change	n.d.	det. IDS 8 pts
4	pt. 28	pt. 24	impr. 4 pts	n.a.	57	56	impr. 1 pts	n.a.	n.a	No changes	no relevant change
4	par. 19	par. 31	det. 12 pts	n.a.	57	56	impr. 1 pts	n.a.	n.a	No changes	no relevant change

^ascores were calculated by the sum of all scores divided by the number of answered items (maximum score 92). A lower score represents a better HRQL
^bUMRS: scores represent the sum scores of section 2, 3 and items A-G of section 4 of the UMRS, calculated by using the UMRS score sheet [14]. A lower score represents less myoclonus; for patient 2, 3 and 4 the scores are the average scores of the two raters; for patient 1 the consensus scores of the two raters are shown in the table (because in the individual scores there was one outlier, so a consensus meeting was organised where the raters rescored all videos together)
^cchange between baseline assessment and 3 months assessment during the MAD
Det. Deterioration, EEG Electroencephalography, HRQL Health-related quality of life, IDS Inventory of depressive symptomatology, impr. improvement, MAD Modified Atkins diet, n.a. not applicable, n.d. no data, par. parents, pt. patient, pts points, UMRS Unified Myoclonus Rating Scale

ISSN: 1750-1172